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--- prnewswire com the-european-medicines-agency-ema-validated-regulatory chemistry-europe onlinelibrary wiley com doi 10 1002 cmdc 202300140Mar 6, 2023 · We show that the efficacy and safety profile of arpraziquantel is similar to that of praziquantel , and arpraziquantel has improved palatability compared with praziquantel Our findings support the potential first-line use of arpraziquantel for preschool-aged children with schistosomiasis --- nature com articles s41591-023-02719-4 Efficacy and safety of praziquantel in preschool-aged and school-aged children infected with Schistosoma mansoni: a randomised controlled, parallel-group, dose-ranging, phase 2 trial - The Lancet Global Health Articles | Volume 5, ISSUE 7, e688-e698, July 2017 --- merckgroup com global-health-ema-validation-arpraziquantel-02-12-2022 Praziquantel is an anthelmintic medication used to treat parasitic worm infections such as schistosomiasis, clonorchiasis, and opisthorchiasis Brand Names Biltricide Generic Name Praziquantel DrugBank Accession Number DB01058 Background Praziquantel is a pyrazino-isoquinolein derivative from the thioxantonic group used as a broad --- thelancet com journals laninf article PIIS1473-3099(23)00048-8 fulltextIntroduction Praziquantel (PZQ) is an essential medicine for the treatment of schistosomiasis (Bilharzia), 1 a disease of poverty that afflicts ∼250 million people worldwide 2 The use and continued efficacy of PZQ is integral to the WHO roadmap of interventions to control schistosomiasis morbidity and to eliminate the disease as a public health problem by 2030 3 WHO estimates that at The first synthesis of praziquantel was in 1972 – almost 50 years ago In 1980 the compound was approved for the treatment of human Schistosomiasis and is still the drug of choice This review summarizes the complex pharmacology of praziquantel and the mode of action on the molecular level, which has recently been elucidated --- merckgroup com en news arpraziquantel-ema-response-15-12-2023 htmlWhat is arpraziquantel used for? The Pediatric Praziquantel Consortium is an international not-for-profit partnership that aims to reduce the global disease burden of schistosomiasis by addressing the medical needs of infected chemistry-europe onlinelibrary wiley com doi 10 1002 cmdc 202300154Jan 23, 2023 · The European Medicines Agency (EMA) Validated Regulatory Application for Arpraziquantel , a Potential Treatment for Schistosomiasis in Preschool-Aged Children Schistosomiasis, endemic in 78 low-income and middle-income countries, is the second most serious tropical disease after malaria Globally, more than 250 million people live with schistosomiasis and 779 million are at risk, resulting in an annual burden of 1·4–3·3 million disability-adjusted life-years 1 Schistosomiasis is one of ten neglected tropical diseases listed as a public health One in 30 people (∼200 million people worldwide) are infected by schistosomiasis, a predominantly African disease, which kills more than 200 000 people each year Given our ongoing interest in neglected diseases and drugs for their treatment, we provide herein the first comprehensive and detailed summary of the chemistry and biology of the This study was funded by the Global Health Innovative Technology Fund, the European and Developing Countries Clinical Trials Partnership, and the healthcare business of Merck KGaA, Darmstadt, Germany (CrossRef Funder ID 10 13039 100009945), which financially supports the Pediatric Praziquantel Consortium with in-kind contributions by partners and grants from the Bill & Melinda Gates Foundation go drugbank com drugs DB01058Does Merck have a regulatory application for praziquantel? Apr 3, 2023 · Investigations on praziquantel (PZQ) started fifty years ago by a cooperation between Bayer AG and Merck KGaA Until today PZQ is the drug of choice for schistosomiasis in human medicine and used in many combinations with antinematode drugs in veterinary medicine People also askMerck is designated as the future Marketing Authorization Holder for African countries Derived from praziquantel, the standard of care treatment developed in the 1970s, arpraziquantel is tailored to meet the needs of preschool-aged children suffering from schistosomiasis This group of approximately 50 million patients currently lacks a Jan 4, 2024 · Artesunate–mefloquine at antimalarial dosage was moderately safe and noninferior to standard-care praziquantel for the treatment of schistosomiasis, predominantly due to S haematobium Who invented praziquantel? What is praziquantel (PZQ)? Dec 15, 2023 · Merck, a leading science and technology company, and the Pediatric Praziquantel Consortium today announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) adopted a positive scientific opinion for arpraziquantel for the treatment of schistosomiasis in children aged 3 months to 6 years In total, 726 children were randomized 1:1 to praziquantel (standard care: 40 mg kg−1 single dose; n = 364) or to artesunate–mefloquine (antimalarial dosage: artesunate 4 mg kg−1 and Tested in clinical development under the responsibility of Merck, arpraziquantel contains the pharmacologically active enantiomer of praziquantel It is a 150mg dispersible tablet The prototype of its pediatric formulation was developed by Astellas in Japan and further optimized by Merck in Germany The manufacturing process served to produce --- thelancet com journals laninf article PIIS1473-3099(23)00059-2 fulltextDec 2, 2022 · European Medicines Agency (EMA) Validates Application for Arpraziquantel to Treat Schistosomiasis in Preschool-Aged Children Merck and the Pediatric Praziquantel Consortium, today announced that the EMA has validated for review the application for arpraziquantel for the treatment of schistosomiasis in preschool chemistry-europe onlinelibrary wiley com doi 10 1002 cmdc 201000202

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