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--- nature com articles s41591-023-02719-4Mar 6, 2023 · Efficacy, safety, and palatability of arpraziquantel ( L - praziquantel ) orodispersible tablets in children aged 3 months to 6 years infected with Schistosoma in Côte d'Ivoire and Kenya: an open-label, partly randomised, phase 3 trial - The Lancet Infectious Diseases Articles | Volume 23, ISSUE 7, P867-876, July 2023 In total, 726 children were randomized 1:1 to praziquantel (standard care: 40 mg kg−1 single dose; n = 364) or to artesunate–mefloquine (antimalarial dosage: artesunate 4 mg kg−1 and --- thelancet com journals laninf article PIIS1473-3099(23)00048-8 fulltextgo drugbank com drugs DB01058Jun 30, 2021 · The chemical compound praziquantel has been developed by Bayer company in Leverkusen, Germany, is now also produced in China and sold worldwide as treatment of human and animal diseases due to infections with tapeworms and trematodes It was used successfully by --- thelancet com journals laninf article PIIS1473-3099(23)00059-2 fulltextPraziquantel is an anthelmintic medication used to treat parasitic worm infections such as schistosomiasis, clonorchiasis, and opisthorchiasis Brand Names Biltricide Generic Name Praziquantel DrugBank Accession Number DB01058 Background Praziquantel is a pyrazino-isoquinolein derivative from the thioxantonic group used as a broad This study was funded by the Global Health Innovative Technology Fund, the European and Developing Countries Clinical Trials Partnership, and the healthcare business of Merck KGaA, Darmstadt, Germany (CrossRef Funder ID 10 13039 100009945), which financially supports the Pediatric Praziquantel Consortium with in-kind contributions by partners --- prnewswire com the-european-medicines-agency-ema-validated-regulatory Dec 2, 2022 · European Medicines Agency (EMA) Validates Application for Arpraziquantel to Treat Schistosomiasis in Preschool-Aged Children Merck and the Pediatric Praziquantel Consortium, today announced that the EMA has validated for review the application for arpraziquantel for the treatment of schistosomiasis in preschool What is arpraziquantel used for? --- merckgroup com global-health-ema-validation-arpraziquantel-02-12-2022 The Pediatric Praziquantel Consortium is an international not-for-profit partnership that aims to reduce the global disease burden of schistosomiasis by addressing the medical needs of infected Introduction Praziquantel (PZQ) is an essential medicine for the treatment of schistosomiasis (Bilharzia), 1 a disease of poverty that afflicts ∼250 million people worldwide 2 The use and continued efficacy of PZQ is integral to the WHO roadmap of interventions to control schistosomiasis morbidity and to eliminate the disease as a public health problem by 2030 3 WHO estimates that at Schistosomiasis, endemic in 78 low-income and middle-income countries, is the second most serious tropical disease after malaria Globally, more than 250 million people live with schistosomiasis and 779 million are at risk, resulting in an annual burden of 1·4–3·3 million disability-adjusted life-years 1 Schistosomiasis is one of ten neglected tropical diseases listed as a public health Where is praziquantel made? Merck is designated as the future Marketing Authorization Holder for African countries Derived from praziquantel, the standard of care treatment developed in the 1970s, arpraziquantel is tailored to meet the needs of preschool-aged children suffering from schistosomiasis This group of approximately 50 million patients currently lacks a Who invented praziquantel? Apr 3, 2023 · The first synthesis of praziquantel was in 1972 – almost 50 years ago In 1980 the compound was approved for the treatment of human Schistosomiasis and is still the drug of choice This review summarizes the complex pharmacology of praziquantel and the mode of action on the molecular level, which has recently been elucidated What is praziquantel (PZQ)? Felpreva® (Vetoquinol), containing tigolaner, emodepside and praziquantel, is a new spot-on formulation • Felpreva is safe and highly efficacious against fleas and ticks for a 3-month period after a single administration in cats • Data from a multicentre study, randomized and blinded European field study are presented •Tested in clinical development under the responsibility of Merck, arpraziquantel contains the pharmacologically active enantiomer of praziquantel It is a 150mg dispersible tablet The prototype of its pediatric formulation was developed by Astellas in Japan and further optimized by Merck in Germany The manufacturing process served to produce Praziquantel – 50 Years of Research Dr Andreas Waechtler, Dr Bertram Cezanne, Dr David Maillard, Dr Rui Sun, Shaofang Wang, Jihua Wang, Dr Achim Harder , In memory of Dr Andreas E F Wächtler (1951–2021), who has been involved in praziquantel research for nearly 20 years of his career as a chemist at Merck KGaA --- merckgroup com en news arpraziquantel-ema-response-15-12-2023 html--- sciencedirect com science article pii S2667114X22000255Nov 1, 2022 · Praziquantel (PZQ) is a pyrazino-isoquinolein derivative from the thioxantonic group with a broad anthelmintic spectrum [1] and has been used successfully in most treatments of humans infected with trematodes and cestodes (e g , schistosomiasis, taeniasis, cysticercosis) Dec 15, 2023 · EMA assessed arpraziquantel under the EU - M4all procedure for high-priority medicines intended for use in countries outside the European Union ; Merck is committed to contribute to the elimination of schistosomiasis as a public health problem by 2030 Aug 12, 2019 · Praziquantel was banned in Europe , so I've written to Aquarium Münster, and they suggested I use cyromazine instead How similar are the two medications, when used as a prophylactic treatment in a QT? Does cyromazine have as wide a spectrum as praziquantel in terms of the diseases that it treats? People also askchemistry-europe onlinelibrary wiley com doi 10 1002 cmdc 202300154chemistry-europe onlinelibrary wiley com doi 10 1002 cmdc 202300140

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