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--- thelancet com journals lanres article PIIS2213-2600(18)30102-4 fulltext--- drugs com mtm olodaterol-and-tiotropium htmlFewer deaths occurred with tiotropium–olodaterol (107 [3%] of 3939 patients) versus tiotropium (121 [3%] of 3941 patients) during the 360 plus 21 days from the first dose of study drug, and time to all-cause mortality was similar with tiotropium–olodaterol compared with tiotropium (HR 0·88, 95% CI 0·68–1·15) See full list on drugs com What is olodaterol and tiotropium? Tiotropium olodaterol (Spiolto ®) is a fixed-dose LAMA LABA combination, administered via a soft-mist inhaler (SMI; Respimat ® Soft Mist™ inhaler), which has demonstrated greater improvements in lung function, symptoms, HRQoL and exercise capacity among patients with COPD than its monocomponents (tiotropium or olodaterol) or placebo in Boehringer Ingelheim today announced submission of Marketing Authorisation Applications in 31 European countries for the once-daily fixed-dose combination of tiotropium + olodaterol in the Respimat® Soft Mist™ Inhaler as a maintenance bronchodilator treatment for patients with chronic obstructive pulmonary disease (COPD) --- nature com articles s41533-016-0002-x--- tandfonline com doi full 10 1080 17476348 2021 2023498Efficacy and safety of tiotropium+olodaterol fixed-dose combination (FDC) compared with the mono-components was evaluated in patients with moderate to very severe chronic obstructive pulmonary disease (COPD) in two replicate, randomised, double-blind, parallel-group, multicentre, phase III trials Patients received tiotropium+olodaterol FDC 2 5 5 μg or 5 5 μg, tiotropium 2 5 μg or 5 μg, or Oct 24, 2022 · In this observational study, we aimed to measure changes in physical functioning, serving as a surrogate for physical activity and exercise capacity, in patients with COPD treated with tiotropium olodaterol fixed-dose combination (FDC) in a real-world setting in Central and Eastern Europe link springer com article 10 1007 s41030-020-00122-9The effectiveness of tiotropium olodaterol in a field-practice scenario has been assessed in some observational studies, which have been conducted in Central Europe and Japan [27–30] However, further evidence from other countries is necessary, since treatment outcomes vary in different cultural and geographical areas [ 31 ] --- europeanpharmaceuticalreview com boehringer-ingelheim-submits-applica For physical functioning, improvements have been observed in patients with COPD participating in a real-world study in CEE after 6 weeks of tiotropium olodaterol therapy [Citation 43] Dual bronchodilator therapy may also help to promote physical activity by a variety of mechanisms in this context, such as reducing breathlessness and SPIOLTO® Respimat® ( tiotropium + olodaterol ) is indicated as a maintenance bronchodilator treatment to relieve symptoms in adult patients with chronic obstructive pulmonary disease (COPD) What is the RR for tiotropium olodaterol? Feb 2, 2017 · Our aim was to investigate the effects of tiotropium + olodaterol on patient-reported health outcomes, breathlessness and night-time rescue medication use in patients with chronic obstructive low potassium level--leg cramps, constipation, irregular heartbeats, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling Common side effects of olodaterol and tiotropium may include: back pain This is not a complete list of side effects and others may occur People also askpro boehringer-ingelheim com spiolto-respimat-for-copd-tiotropium-olodate Patients with COPD often have reduced physical activity, which can impair health status Real-world data can provide valuable information on the health and functional status of patients with COPD treated with tiotropium olodaterol AERIAL® (ClinicalTrials gov [NCT03165045][1]) was a German, non-interventional study of patients with COPD receiving treatment with tiotropium olodaterol under Jun 2, 2014 · Abstract Efficacy and safety of tiotropium + olodaterol fixed-dose combination (FDC) compared with the mono-components was evaluated in patients with moderate to very severe chronic obstructive pulmonary disease (COPD) in two replicate, randomised, double-blind, parallel-group, multicentre, phase III trials Does tiotropium & olodaterol improve quality of life in chronic obstructive pulmonary disease? Tiotropium and olodaterol in the prevention of chronic obstructive pulmonary disease exacerbations (DYNAGITO): a double-blind, randomised, parallel-group, active-controlled trial - The Lancet Respiratory Medicine Articles| Volume 6, ISSUE 5, P337-344, May 2018 Download Full Issue Download started --- pharmaceutical-technology com newsboehringers-spiolto-respimat-copd-t Olodateroland tiotropium is a combination medicine used to prevent airflow obstruction and reduce flare-ups in adults with COPD (chronic obstructive pulmonary disease), including bronchitis and emphysema Olodaterol and tiotropium is for use only in people with COPD and should not be used to treat asthma Olodaterol and tiotropium may also be used openres ersjournals com content 7 3 00004-2021erj ersjournals com content 45 4 969Mechanism of Action SPIOLTO® Respimat® is a fixed dose combination inhalation solution containing the long-acting muscarinic receptor antagonist (LAMA) tiotropium, and the long-acting beta agonist (LABA) olodaterol, which is delivered via the Respimat® soft mist inhaler device 1 The two active ingredients provide additive bronchodilation due to their different modes of action Boehringer’s Spiolto Respimat COPD therapy approved in European countries Boehringer Ingelheim Spiolto Respimat (tiotropium olodaterol) once-daily maintenance treatment has received regulatory authority approvals in first European countries, to relieve symptoms in adult patients with chronic obstructive pulmonary disease (COPD) Does tiotropium olodaterol cause adverse events? Tiotropium + olodaterol 5 5 µg significantly reduced night-time rescue medication usage Results from four in-depth studies show that a combined inhaler is very effective for treatment of

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