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--- nature com articles s41401-021-00835-whospitalpharmacyeurope com colchicine-gains-fda-approval-for-cardiovascul Jan 19, 2022 · As a potent anti-inflammatory drug in treating inflammation-associated disorders, colchicine is proposed to exhibit cardiovascular protective action in patients with CVD In the later sections, In conclusion, the best available evidence indicates that low-dose colchicine reduced composite and individual cardiovascular outcomes in patients with coronary disease, when added to contemporary treatment with antiplatelet agents and lipid-lowering therapy Supplementary material Supplementary material is available at European Heart Journal Mar 9, 2023 · Colchicine , which was already used by the ancient Egyptians, has recently experienced a renaissance in various medical disciplines, including dermatology However, due to the potentially significant side effects of systemic use, many clinicians are cautious in their use of colchicine Anti-inflammatory treatment with colchicine is a therapeutic tool to be added on top of the most advantageous standard of care in patients still at high risk of recurrent cardiovascular events • The low cost of colchicine and the reassuring data on long-term safety strenghten the rationale to use this drug for cardiovascular prevention Low-dose colchicine (0 5 mg daily) is now FDA-approved for secondary prevention in patients with coronary disease and will be increasingly prescribed in clinical practice In this State-of-the-Art Review, data were collated from contemporary systemic reviews of case reports, drug registries, and placebo-controlled trials that assessed specific --- ejinme com article S0953-6205(23)00464-8 fulltextPeople also askJan 3, 2024 · The approval of colchicine revolutionised the therapeutic algorithm for cardiovascular prevention bringing to the forefront the long-term direct targeting of inflammation • Colchicine is an ancient herbal drug derived from Colchicum autumnale It was first used to treat familial Mediterranean fever and gout Based on its unique efficacy as an anti-inflammatory agent academic oup com eurheartj advance-article-abstract doi 10 1093 7643185--- thelancet com journals lanres article PIIS2213-2600(21)00462-8 fulltextIs colchicine an athero-inflammatory drug? Colchicine has been used to treat diverse pathologies in different areas of medicine, including rheumatology and cardiology During the COVID-19 pandemic, colchicine has been considered a good therapeutic option because of its effects on the parts of the immune system involved in SARS-CoV-2 infection and acute respiratory distress syndrome (ARDS), including its effects on the chemotaxis of Colchicine is a tricyclic alkaloid with anti-inflammatory properties extracted from the herbaceous Colchicum autumnale plant and first isolated and synthesized in the 19th century [1] May 7, 2021 · Colchicine is a unique, sophisticated anti - inflammatory agent that has been used for decades for the prevention of acute inflammatory flares in gout and familial Mediterranean fever In recent years, clinical trials have demonstrated its potential in a range of cardiovascular (CV) conditions academic oup com eurheartj article 42 28 2765 6188997According to the recommendations of the European League Against Rheumatism (EULAR) from 2016, a necessary systemic therapy with colchicine may be continued under close monitoring during both pregnancy and breast-feeding after considering the risk profile 36 A meta-analysis performed in 2020 also found no significant differences with respect to academic oup com eurheartj article 36 42 2921 2293375onlinelibrary wiley com doi 10 1111 ddg 14961What is colchicine based on? Mar 26, 2021 · Our meta-analysis indicates that low-dose colchicine reduced the risk of MACE as well as that of myocardial infarction, stroke, and the need for coronary revascularization in a broad spectrum of patients with coronary disease After a median of 28 6 months, significantly fewer patients assigned to colchicine experienced a primary endpoint event (hazard ratio, HR = 0 69, 95% CI 0 57 – 0 83, p < 0 001) Other work has also revealed how colchicine is effective in patients with chronic coronary disease both prior to and following an acute coronary syndrome --- amjmed com article S0002-9343(21)00098-X fulltextThe medicinal properties of colchicine have been recognized for centuries Although previously used for gout and familial Mediterranean fever, its immune-modulating, anti-inflammatory, and antifibrotic effects are increasingly recognized as beneficial in the treatment of cardiovascular disorders In this systematic review, we summarize the current evidence on colchicine's effectiveness in 1 Major advances have occurred in therapy with the first multicentre randomized clinical trials 10, 11, 13–15 Colchicine has been demonstrated as a first-line drug to be added to conventional anti-inflammatory therapies in patients with a first episode of pericarditis or recurrences in order to improve the response to therapy, increase academic oup com eurheartj article 42 28 2745 6271392Is colchicine safe for dermatology? What is colchicine used for? Colchicine is a unique, sophisticated anti-inflammatory agent that has been used for decades for the prevention of acute inflammatory flares in gout and familial Mediterranean fever In recent years, clinical trials have demonstrated its potential in a range of cardiovascular (CV) conditions Colchicine is avidly taken up by leucocytes, and its Apr 10, 2024 · Low-dose colchicine (0 5 mg daily) is now FDA-approved for secondary prevention in patients with coronary disease and will be increasingly prescribed in clinical practice

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