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--- healio com news resolor-safely-improved-chronic-constipation-in-men Dosage Direction for Use Adult 2 mg once daily Older people >65 yr & patient w severe hepatic impairment 1 mg once daily May be increased to 2 mg once daily if needed Patient w severe renal impairment 1 mg once daily Click to view Resolor detailed prescribing information Side Effects Nausea, abdominal pain, diarrhea, or headache commonly occur during the first 1 to 2 days of treatment Dizziness or tiredness may also occur If any of these effects last or get Resolor belongs to a group of gut motility enhancing medicines (enterokinetics) It acts on the muscle wall of the gut, helping to restore the normal functioning of the bowel The tablets are used for the treatment of chronic constipation in women in whom laxatives do not work well enough go drugbank com drugs DB06480Jun 3, 2015 · Zug, Switzerland – 03 June 2015 – Shire plc (LSE: SHP, NASDAQ: SHPG) announced today that Resolor (prucalopride) has been approved by the European Commission for use in adults for the symptomatic treatment of chronic constipation in whom laxatives fail to provide adequate relief --- takeda com newsroom resolor-eu-male-indication-press-releasemedikamio com en-gb drugs resolor-2-mg-film-coated-tablets pilView all Resolor is a selective, high-affinity 5-HT4 receptor agonist, which helps to stimulate bowel motility “Constipation can cause severe symptoms, affect quality of life and lead to significant healthcare resource utilisation,” commented Professor Yan Yiannakou, Principal trial investigator of the Resolor male study and Professor of --- europeanpharmaceuticalreview com ema-approves-resolor-for-use-in-men- Resolor is used to treat symptoms of chronic (long-term) constipation in adults for whom laxatives (medicines that trigger bowel movements) do not work well enough The medicine can only be obtained with a prescription Side Effects Nausea, abdominal pain, diarrhea, or headache commonly occur during the first 1 to 2 days of treatment Dizziness or tiredness may also occur If any of these effects last or get Generic Name Prucalopride DrugBank Accession Number DB06480 Background Prucalopride is a dihydrobenzofurancarboxamide derivative from the benzofurane family that selectively stimulates 5-HT4 receptors and thus, it presents enterokinetic properties 2 The high selectivity of prucalopride allowed further development as it prevented the cardiac adverse reactions observed due to non-target Jun 3, 2015 · Resolor is a selective, high-affinity 5-HT4 receptor agonist, which helps to stimulate bowel motility “Constipation can cause severe symptoms, affect quality of life and lead to significant healthcare resource utilisation,” commented Professor Yan Yiannakou, Principal trial investigator of the Resolor male study and Professor of --- drugs com uk resolor htmlgut bmj com content 58 3 357--- webmd com drugs 2 drug-162142 prucalopride-oral detailsreference medscape com drug motegrity-prucalopride-1000289 Abstract Objective: To determine the efficacy, impact on quality of life (QOL) and safety of prucalopride, a selective, high-affinity 5-HT 4 receptor agonist, in patients with chronic constipation wchh onlinelibrary wiley com doi 10 1002 psb 639Mild or moderate (CrCl ≥30 mL min): No dosage adjustment necessary Severe (CrClOne film-coated tablet of Resolor 2 mg contains 2 mg prucalopride (as prucalopride succinate) The other ingredients are: Lactose monohydrate, microcrystalline cellulose, colloidal silicon dioxide, magnesium stearate, hypromellose, triacetin, titanium dioxide (E171), macrogol 3000 The 2 mg tablet also contains iron oxide red (E172), iron oxide Results from a recent phase 3 study showed that Resolor is a safe, effective and well-tolerated treatment for men with chronic constipation Resolor (prucalopride, Johnson & Johnson) is a 5 Prucalopride (Resolor) is a new treatment for women with chronic constipation who have not responded to conventional laxatives In our New products review, Steve Chaplin presents the data relating to its efficacy and adverse effects and Drs Paul Blaker and Mark Wilkinson comment on its place in the treatment of constipation Objective: To determine the efficacy, impact on quality of life (QOL) and safety of prucalopride, a selective, high-affinity 5-HT4 receptor agonist, in patients with chronic constipation Methods: In this multicentre, randomised, placebo controlled, parallel-group, phase III study, patients with chronic constipation (two or fewer spontaneous complete bowel movements (SCBM) week) received 2 mg About Resolor (prucalopride) Resolor is a selective, high-affinity 5-HT 4 receptor agonist with gastrointestinal prokinetic effects 1 Resolor binds to and stimulates 5-HT 4 receptors, which are involved in the stimulation of high-amplitude propagated contractions (HAPCs) and co-ordination of bowel motility 4-7 In an integrated analysis of six Resolor 2 mg once a day was also compared with placebo in another main study involving 374 men with chronic constipation The main measure of effectiveness in the studies was the number of patients who completely emptied their bowels at least three times a week over a 12 week period without the help of laxatives

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